HOW TO MAKE SPLENDA® IN 5 EASY STEPS

Splenda® is basically made by adding three chlorine atoms to sucrose. The chemical formula for Splenda® is
1,6-dichloro-1, 6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside. It is also known as sucralose.

According to SRI Consulting PEP Review #90-1-4 (July 1991),
the following is the process by which sucralose is synthesized:

1. sucrose is tritylated with trityl chloride in the presence of dimethylformamide
and 4-methylmorpholine and the tritylated sucrose is then acetylated with acetic anhydride,

2. the resulting TRISPA (6,1′,6′-tri-O-trityl-penta-O-acetylsucrose) is chlorinated with
hydrogen chloride in the presence of toluene,

3. the resulting 4-PAS (sucrose 2,3,4,3′,4′-pentaacetate) is heated in the presence of
methyl isobutyl ketone and acetic acid,

4. the resulting 6-PAS (sucrose 2,3,6,3′,4′-pentaacetate) is chlorinated with thionyl chloride
in the presence of toluene and benzyltriethylammoniumchloride, and

5. the resulting TOSPA (sucralose pentaacetate) is treated with methanol (wood alcohol)
in the presence of sodium methoxide to produce sucralose.

Brings back memories of Organic Chemistry class. Ahhh… good times.

DISCLAIMER: The views and opinions expressed in this comic are solely those of the cartoonist
and should not be attributed to the powerful and evil Abstruse Goose Corporation or any of its
worldwide subsidiaries. We are currently unaware of any scientific study which shows that
Splenda® may be harmful to human health in any way…
but… I mean… chlorine? toluene? methanol? DAYAMN!… I’m just saying.

“What’s in a name? That which we call sucralose
By any other name would taste just as sweet.“